TJ Cradick’s Selected Patents and Links (excluding unpublished filings)
WIPO (PCT) WO2023196647A1
TJ Cradick
Compositions and methods for inactivating viral targets or gene editing other sequences using microhomology-mediated end joining (MMEJ) DNA repair. For example, the described methods better allow for the selection of targets sites predicated to provide a higher rate of the desired outcome.
US20210363521A1
Police, S Chou, TJ Cradick, R Ng, Y Yang
Cas systems and compositions that target the dystrophin gene. Also provided are methods for using the CRISPR/Cas systems, vectors and compositions in methods
for genome engineering to correct a mutant dystrophin gene, and for treating Duchenne muscular dystrophy.
Patent Application WO2019092505A1
Seshi Police, Song Chou,TJ Cradick, Robert Ng
The invention relates to self-inactivating/self-targeting CRISPR-Cas or CRISPR-Cpfl systems, to related genetically modified cells, and to methods
of controlling Cas9 expression. The invention also relates to methods of genetically modifying a cell, to nucleic acids for use in a self-inactivating CRISPR/Cas or CRISPR/Cpfl system and to related pharmaceutical compositions.
WO2017134529A, EP3411078A1
TJ Cradick
WO2016135558A2, AU2016225179B2
Matt Porteus, TJ Cradick, G Bao & C Lee.
Materials and methods for treating hemoglobinopathies. More specifically, the application provides methods for producing progenitor cells that are
genetically modified via genome editing to increase the production of fetal hemoglobin (HbF), as well as modified progenitor cells (including, for example, CD34+ human hematopoietic stem cells) producing increased levels of HbF, and methods
of using such cells for treating hemoglobinopathies such as sickle cell anemia and β-thalassemia.
US10354746B2, WO2015113063A1, US11315659B2
TJ Cradick,
US11120889B2
EJ Fine, TJ Cradick, Y Lin & G Bao.
Provided herein are systems and methods for identifying the off-site cleavage loci and predicting the activity of engineered endonucleases for a given genome. It is
expected that these tools and methods will be useful for designing nucleases and other related DNA binding domains (e.g. TAL effectors) for genomic therapy and engineering.
US20120297495A1
AP McCaffrey and TJ Cradick.
Methods for targeted inactivation of viral genomes. In one embodiment, zinc-finger proteins in which DNA binding sites are altered such that they recognize and bind different, desired DNA sequences contained in hepatitis B virus (HBV) and that
include nuclease domains are used for inactivation (Zinc Finger Nucleases = ZFNs). Other embodiments for targeted inactivation of viral genomes use small nucleic acid molecules, such as short micro-RNA molecules or short hairpin RNA molecules
capable of mediating RNA interference (RNAi) against HBV.